Effects of high frequency oscillatory ventilation on newborns with critical neonatal respiratory distress syndrome

Objective To evaluate the effects of high frequency oscillatory ventilation(HFOV) on treating critical neonatal respiratory distress syndrome(NRDS). Methods Forty premature newborns with critical NRDS were divided into two groups: research group(HFOV plus SIMV,20 cases) and control group(SIMV or A/C,20 cases). Blood gas analysis(after giving mechanical ventilation 1 h,12 h,24 h),mechanical ventilation time and complications(such as pneumothorax,intracranial hemorrhage) were compared between the two groups. Results One hour after giving mechanical ventilation,PaO2 was increased and PaCO2 was decreased in the research group,and the difference between the two groups was statistically significant(t=3.83,2.09,P0.05)。But there were no statistically significant in the difference of PaO2 and PaCO2 on 12,24 hours after therapy between the two groups(t=1.03,0.23; 0.33,0.55,P0.05). The mechanical ventilation time in the research group was shorter than that in the control group(t=3.37,P0.05)。Compared with the control group,the incidence of pneumothorax in the research group was significantly lower(χ2=4.32,P0.05). But no statistic significance was found in the incidence of intracranial hemorrhage between two groups(χ2=0.43,P0.05)。Conclusions HFOV is a safe and effective mechanical ventilation method for NRDS.