Clinical analysis of high-frequency oscillatory ventilation in treatment of severe neonatal respiratory distress syndrome

Objective To evaluate the effects of high frequency oscillatory ventilation( HFOV) in treatment of neonatal respiratory distress syndrome( NRDS). Methods 45 premature newborns with NRDS were divided into two groups: a research group( HFOV,25cases) and a control group( SIMV,20cases). Blood gas analysis( 1 h,12 h,and 24 h after mechanical ventilation),duration of mechanical ventilation and hospitalization,clinical efficacy,and incidence of mechanical ventilation complications were compared between the two groups. Results One hour after giving mechanical ventilation,Pa O2 increased and Pa CO2 decreased in the research group,and the difference between the two groups was statistically significant( P 0. 05). But there was no statistically significant difference of Pa O2,Pa CO2 and OI at the beginning,12 h,and 24 h of the therapy between the two groups. The mechanical ventilation time and hospitalization in the research group was shorter than in the control group( P 0. 05). There were no significant differences between the two groups in the incidences of PAL,BPD,IVH and survival rates( P 0. 05). Conclusion HFOV can rapidly improve pulmonary respiratory function,decrease the duration of mechanical ventilation and hospitalization. HFOV is an effective and safe mechanical ventilation method for severe NRDS.