High Frequency Oscillation Ventilation for Neonatal Respiratory Distress Syndrome

Objective To study the value of high-frequency oscillatory ventilation(HFOV) in treating the neonatal respiratory distress syndrome(NRDS).Methods Sixty two premature infants with NRDS were divided into the experimental group(32 cases) and control group(30 cases).The experimental group received HFOV,whereas control group received the conventional mechanical ventilation and one time quick drip of Curosurf(200 mg/kg) by tracheal tube at beginning of the treatment.The PaO2,PaCO2,A-aDO2 and OI before and after the treatment were observed and compared.Results One hours after the HFOV therapy,PaCO2,OI were obviously decreased[PaCO2:(50.9±8.9) mm Hg,OI:6.0±2.5] and PaO2,A-aDO2 was increased[PaO2:(72.2±12.5) mm Hg,A-aDO2:(0.45±0.11) mm Hg] in the experimental group,and the difference between the two groups was statistically significant(P0.01,P0.05);But there were no statistically significant in the difference of PaO2,PaCO2,OI and A-aDO2 on 3,6,12,24 hours after therapy between two groups.Conclusion HFOV is a safe and effective mechanical ventilation method for NRDS.