The relationship between insulin level and blood-lipid in patients of coronary heart disease

Objective To explore the relationship between the level of blood insulin and that of blood-lipid in patients with coronary heart disease. Methods The levels of blood insulin, blood sugar, triglyceride (TG), total cholesterol (TC) and high-density lipoprotein- cholesterol (HDL-Ch) were measured by radioimmunoassay (RIA), hexokinase method (HK), GPO-PAP method, and CHOD-PAP method respectively. Total 42 cases of coronary heart diseases were included in the study, among which 21 were confirmed by coronary arteriography; and 32 healthy subjects were also studied as control group. Results The levels of blood insulin, blood sugar and triglyceride (TG) in patients of coronary heart disease are all significantly higher than those in the control group, while the level of HDL-Ch was remarkably reduced. The blood insulin was positively correlated with TG and negatively correlated with HDL-Ch. Conclusion The results suggest that hyperinsulinemia exists in patients of coronary heart disease, which is closely associated with the abnormity of lipid metabolism.