Correlation of insulin sensitivity and blood lipid with the severity of coronary artery disease

Objective To investigate the relationship of insulin sensitivity and blood lipid with the extent and severity of coronary artery lesions in patients with coronary heart disease.Methods Blood lipid,fasting glucose,fasting insulin and insulin sensitivity parameters were determined in 100 patients with positive coronary angiography results(coronary heart disease group),50 patients with negative coronary angiography results(non-coronary heart disease group)and 50 healthy controls.Correlation of the severity of coronary artery lesions with blood lipid,glucose,insulin and the insulin sensitivity parameters was respectively studied with linear regression analysis,and the stepwise regression analysis was used to assess independence of associations.Results Blood lipid,insulin and insulin sensitivity index except for total cholesterol and glucose had statistic difference between coronary heart disease group and control group(P0.05).High density lipoprotein and insulin sensitivity index were significantly lower in coronary heart disease group than those in non-coronary heart disease group.Insulin and insulin-sensitivity index in coronary heart disease group were remarkably correlated with the severity of coronary artery lesions(r=0.25,P0.05;r=-0.32,P0.01).The number of diseased vessel was not correlated with any independent variables.Stepwise regression analysis showed that only insulin sensitivity index was independently correlated with the severity of coronary lesions.Conclusion The coronary heart disease presents the insulin resistance,hyperinsulinism and lipid metabolism abnormity,which are all the risk factors of coronary heart disease.Insulin sensitivity index is the only independently variable correlated with the severity of coronary lesions.