Significance and expression of JNK in neuron of hippocampus in mice with vascular dementia

Objective To explore the expression and the significance of JNK in neuron of hippocampus in mice with vascular dementia(VD) and its role in the development of VD.Methods 66 mice were divided into three groups(the normal group,sham operation group,and the VD models group).The mice of VD models group were subjected to ischemia and reperfusion repeatedly by ligation of bilateral common carotid arteries to establish the VD models.The behavioral changes of the mice were investigated by step-down test and morris water maze test.The Changes of immunohistochemical expression of JNK were observed in the three groups.Results Compared with the normal group and sham operation group,the learning test showed that the response time and the swimming time of VD models group were prolonged,and the error times were also increased;In the memory test,the latency time of VD models group was shortened,the swimming time was prolonged,and the error times were increased(P 0.05).The immunohistochemical expression of JNK in neuron of hippocampus in VD models group was also increased,compared with the other two groups(P 0.01).Conclusion It suggests that the decline of cognition and memory function is related to the increasing of JNK expression in neuron of hippocampus in VD mice.