Experimental research about the effect of glycosides( GCs) on vascular dementia( VD) rats model of cognitive function and NF-κB expression in hippocampal brain areas

Objective To observe the effect of glycosides( GCs) on vascular dementia( VD) rats model of learning and memory dysfunction,explore the prevention and cure function of GCs on VD; Methods VD rats model was establishde by bilateral common carotid artery ligation( 2-VO); and divided into VD model group,sham-operation group,GCs low、middle、high dose treatment groups and drug control group. Spatial learning and memory ability of rats was detected by Mories water maze; and NF-κB expression were investigated by Immunohistochemistry; Results( 1) Eescape latency period of VD rats extended obviously compared with the control group( P 0. 01); but the escape latency significantly shortened after treatment;( 2) NF-κB expression in hippocampus is significantly increased compare with the VD group; and decreased after GCs treatment; Conclusion GCs can decrease expression of NF-κB,so as to effectively improve the learning and memory ability of VD model rats.