Expression of nm23-H_1 and p16 Gene and its Clinical Significance in Gallbladder Carcinoma

objective To evaluate the significance of expression of nm23 H 1 and p16 gene in gallbladder carcinoma.Methods 58 cases including 42 cases of gallbladder carcinoma and 16 cases of benign gallbladder diseases were analyzed for protein expression of nm23 H 1 and p16 gene by immunohistochemistry.Results The positive rate of nm23 H 1 and p16 was 40 5% and 47 6%,which was markedly lower than that in benign diseases and was positively correlated to clinic stage,metastasis and prognosis.Conclusions The detection of the expression of nm23 H 1 and p16 can act as an indicator for metastasis and prognosis in gallbladder carcinoma