2007•Chinese Journal of Clinical Oncology and RehabilitationRequires access
Expression of PTEN gene in non-small cell lung cancer
Sheng Yang
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Abstract
ObjectiveTo investigate the expression of PTEN gene in non-small cell lung cancer(NSCLC) and analyze the role of PTEN gene in lung tumorigenesis.Methods Immunohistochemical stain was used to determine the expression of PTEN in 20 cases of normal lung tissues and benign pulmonary lesion tissues and 143 cases of non-small cell lung cancer.Results The negative rate of loss of PTEN expression in normal lung tissues and benign pulmonary lesion tissues was 100.0% which was significantly higher than that in tissues of non-small cell lung cancer 57.3%(P0.001).The expression of PTEN gene was closely associated with cell differentiation,TNM stages and lymph node metastasis in lung cancer patients (P0.001). A marked reduction of PTEN protein expression was observed more frequently in patients with smoking history than in patients without smoking history(P=0.003). Furthermore,loss of PTEN protein expression in non-small cell lung cancer was associated with a poorer survival of patients (P0.001).Conclusion The results suggest that loss of PTEN protein expression is concerned with carcinogenesis of NSCLC and be an independent poor prognostic factor.