Effect of Mannitol Use Time to Early Condition in Hypertensive Cerebral Hemorrhage

Objective To observe the effect of mannitol on cerebral hemorrhage of hypertension early disease.Methods 105 early cases of hypertensive cerebral hemorrhage were selected,randomly divided into A,B and C group of each 35 cases,patients of group A use the mannitol in after 12 hours of the onset,patients of group B use the mannitol in 12~24 hours,and patients of group C only with furosemide intravenous injection of 40mg 1~2 times in 24 hours and began to use the mannitol later.Observation the patients′ increased intracranial pressure performance,brain hematoma size,cerebral edema degree and the neural function defect scale in 48 hours and compared with the relevant indicators of their admission respectively.Results Increased intracranial pressure,the 3 groups after treatment of cerebral hematoma enlargement,brain edema,increased incidence of comparison,the differences were statistically significant(P0.05);B,C between the two groups,the difference was not statistically significant(P0.05).B group of 48h neural function defect score was the lowest,there was significant difference between 3 groups(F=13.86,P0.05).Conclusion The use of mannitol for patients with high blood pressure cerebral hemorrhage in 12 hour of onset may lead to Cerebral hematoma enlargement,cerebral edema and neurological deficit aggravation and safer with mannitol 125 ml a time in 12~24 hours,which is helpful to lighten the neural function defect.