Influence of half-dose mannitol on early hematoma in hypertensive cerebral hemorrhage

Objective To probe into the influence of half-dose mannitol on early enlargement of hematoma in hypertensive cerebral hemorrhage. Methods 102 patients with hypertensive supratentorial nomthalamic cerebral hemorrhage and light intracranial hypertension, and with less than 30ml of hematoma volume determined by cranial CT within 6h after the onset were randomly divided into a group in which half-dose mannitol was used (n=34) or a group in which furosemide was used(n=34), or a group mannitol was not used (n=34). Cranial CT was redone at 48h. If the volume of hemato increased by 33%, it was named early enlargement of hematoma. The influence of using mannitol within 24h after the onset on early enlargement of hematoma was analyzed. Results 13 (38.2%) patients in group A had early enlargement of hematoma, and 4 (11.8%) patients in group B and 3 (8.8%) patients in group C had early enlargement of hematoma. There was significant difference between them(P0.05). Conclusions Use of half-dose mannitol within 24h after the onset may increase the incidence of early enlargement of hematoma in patients with hypertensive cerebral hemorrhage within 24h after the onset. And half-dose mannitol should not be used blindly.