Study on the Effect of Mongolian Medicine PRAUP on Experimental Rat Gastric Ulcer

Objective:To observe the effect of Mongolian medicine proved recipe anti-ulcer powder(PRAUP)on three kinds of experimental rats' gastric ulcers,including stress gastric ulcer,alcohol gastric ulcer and pylori-ligation gastric ulcer.Method:Healthy Wistar rats were randomly divided into 3 groups.Each group included 5 small groups as model group,3 different doses of PRAUP groups(2.26,1.13,0.56 g·kg-1),and Ranitidine group(0.15 g·kg-1)or Colloidal bismuth pectin group(0.25 g·kg-1).Each small group consisted of 10 animals.Every medication group was continuously administrated once a day for 7 d.The model group was given same volume of water once a day for 7 d.After the final administration,animals were made the ulcer models.After killed,appearances and areas of rats' ulcers were totally visual studied and taken pictured by ipWin software,gastric total acidities and pepsin activities of the all were measured to research effect of the medicine on the each ulcer.Result:Compared with model group,the PRAUP could reduce areas of stress gastric ulcer of rats evidently(P0.05 or P0.01),control amount points and areas of alcohol gastric ulcer of rats markedly(P0.05 or P0.01),and could restrain gastric total acidities and pepsin activities of pylori-ligation gastric ulcer of rats(P0.05).Conclusion:The PRAUP has the obvious preventive effect on experimental rats' gastric ulcer and protective effect on gastric mucosa of rats.