Analysis of cytogenetic abnormalities of the patient with amenorrhea

Objective: To analyse the cytogenetic examination results to investigate the effect of chromosome (abnormalities) on amenorrhea.Method: The routine cytogenetic analysis was performed, including the chromosome G band analysis and karyotype analysis of the cultured peripheral blood lymphocytes.Results: One hundred and thirty-seven cases were found with chromosome abnormalities in 234 (patients) with primary amenorrhea. The incidence of chromosome abnormality was 58.6%. In those with secondary amenorrhea, the incidence of chromosome abnormality was 13.6%. The reported (abnormalities) included the numeric and structural abnormalities of X chromosome, 46,XY, 45,X0/46,XY, and the structural abnormality of autosome. Conclusion: Chromosome abnormality is one of the main causes of amenorrhea. Karyotype analysis of chromosome is absolutely necessary for the diagnosis and treatment of patient with amenorrhea.