Analysis of cytogenetic examination in patients with 126 cases of primary amenorrhea

Objective:To analyse the cytogenetic examination result of chromosome abnormalities on primary amenorrhea,and to assist in its clinical diagnosis.Methods:The routine cytogenetic analysis was performed,including the chromosome G band analysis and karyotype analysis of the cultured peripheral blood lymphocytes.Results:Forty three cases were found with chromosome abnormalities in 126 patients with primary amenorrhea.The incidence of chromosome abnormalities was 34.1%(43/126).Thirty three cases were fimnd with anomaly of chromosome X,which involved the number and structure abnormalities.Nine cases were found having Y chromosome.One case was found with autosomal abnormalities.The incidence of the three chromosome abnormalities was 76.7%(33/43),21.0%(9/43)and 2.3%(1/43)respectively.Conclusion:Chromosome abnormalities was one of the main causes of primary amenorrhea.Karyotype analysis of chromosome was necessary for the diagnosis and treatment of patients with primary amenorrhea.