Relationship between glycosylated hemoglobin A_1c level and angiographical characteristics of coronary atherosclerosis

Objective To explore relationship between the level of serum glycosylated hemoglobin A1c and the extent of cornoary lesions in coronary heart disease(CHD).Methods The study concluded 116 consecutive patients and divided them into simple CHD gruop,CHD accompanied type 2 diabetes mellitus(T2DM)and control gruop(n=35).And divided them into single-vessel lesin group(n=31),double-vessel lesin group(n=27),multi-vessel lesin group(n=23)and control gruop(n=35)according to the results of angiography.Correlation between HbA1c levels and severity of coroary atherosclerosis has been analyzed based on the Gensini's score of coronary atherosclerosis.Results There were significant differences between groups of serum HbA1c levels.With the increment of coronary degree,serum HbA1c levels presented a strong positive-correlation with Gensini scores(r=0.314,p0.001).Conclusion The level of serum HbA1c was significantly associated with the severity of coronary atheroscleros.The investigation is useful for prediction of coronary lesions.