Researches on lipid peroxidation of bronchoalveolar lavage and lung in premature rat with chronic lung disease

Objective: To investigate dynamic changes of lipid peroxidation of bronchoalveolar lavage and lung in hyperoxia-induced chronic lung disease (CLD). Methods: Malondialdehyde (MDA) concentration and superoxide dismutase (SOD) activity from lung specimen of day 1,3,7,14 and 21 in 80 premature rat with hyperoxia-induced CLD and 80 control premature rats were assayed with double wavelength scanning by spectrophotometer. Results: SOD activity was no significant difference among any groups. MDA level was increased in day3, and peak level was in day 7, and then was decreased gradually but still maintained at higher level than control group at day 21. Conclusions: Injury of oxygenic free redical in lung companies with the process of hyperoxia-induced CLD; The level of MDA reacts indirect lung injuy.