Effects of captopril in treatment of acute pancreatitis and its influence on serum C reactive protein

Objective To evaluate the effect of captopril in treatment of acute pancreatitis and its influence on serum C reactive protein （ CRP） .Methods 100 cases of acute pancreatitis patients were randomly divided into the control group and observation group,50 cases in each group.The control group was treated with fasting,gastroin-testinal decompression,somatostatin, anti-inflammatory and other conventional treatment, while the observation group was given captopril on basis of routine treatment,the effective rate after 7 days of treatment,pain relief time,amylase returned to normal time,pancreatic edema improved time,serum CRP before and after treatment were compared be-tween the two groups of patients.Results The effective rate after 7 days of treatment of the observation group was 86%,which was significantly higher than 72%of the control group（χ^2=7.334,P〈0.05）;The pain relief time,am-ylase returned to normal time,pancreatic edema improved time of the observation group after treatment were （1.75 ± 0.44）d,（3.49 ±1.22）d,（7.50 ±2.39）d,respectively,which of the control group were （2.25 ±0.58）d,（4.25 ± 1.59）d,（9.25 ±2.87）d,respectively,there were statistically significant difference between the two groups（t1 =3.55,t2 =4.18,t3 =8.33,all P〈0.05）;the serum CRP level of the observation group after treatment was （10.39 ± 3.66）mg/L,improved obviously compared to （25.46 ±8.33）mg/L of the control group,the differences between the two groups was statistically significant（t=11.45,P〈0.05）.Conclusion Captopril has a good effect in treatment of acute pancreatitis,which can effectively improve the level of serum CRP. Key words: Pancreatitis; C reactive protein; Captopril