Association between gastric ulcer in active stage combined with bile reflux and "poison-heat" in TCM

[Objective]To study the effect of Xiaoyongkuidekang Granule(XG)on bile reflux in patients with gastric ulcer of active stage.[Methods]Three hundred patients of gastric ulcer with bile reflux in active stage were selected with features of gastric syndrome in TCM and divided into treatment group and control group,employing double-blinded /simulation randomized control trial.One hundred and fifty patients in the tratment group were treated with XG and 150 patients in the control group with Kuiyang capsule.Condition of bile reflux was observed by gastroscope and symptom scores of TCM before and after the treatment were collected and analyzed.[Results]There were 8 cases loss in the treatment group and 6 cases loss in the control group.Bile reflux grade quantizing score before and after treatment in both groups showed significant difference.Cure rate and total effective rate of the treatment group were 45.1%(64/142)and 99.3%(141/142)respectively,those in the control group were 6.9%(10/144)and 91.0%(131/144)respectively,showing significant difference between the two groups(P0.01).[Conclusion]XG ameliorated bile reflux in patients with gastric ulcer in active stage,improving symptoms,which provided evidence that poison-heat was the etiopathogenisis of gastric ulcer in active stage and bile reflux was an essential factor of poison-heat.