Efficacy of home made hydrotalcite in treating bile reflux gastritis and 24-hour intragastric bile monitoring

Objective To evaluate the efficacy and safety of two kinds of hydrotalcite, Weidimei and Talcid, in treating bile reflux gastritis. Methods Thirty patients with bile reflux gastritis confirmed by endoscopy were equally divided into experimental group (Weidimei) and control group (Talcid). The patients were given Weidimei or Talcid both at the dose of 1.0 g 3 times a day for 4 weeks, respectively. The severity of the symptoms including abdominal pain, regurgitation, nausea and vomiting of bile were investigated before and after the treatment. Twenty four hour bile in stomach was monitored. Results The severity of all symptoms greatly decreased after the treatment in two groups ( P 0.05). The total efficiency was 100%. The mean disappearance time of abdominal pain was (7.2±3.1) days in experimental group, and (6.9 ±4.8) days in control group . The total fraction time of bile reflux decreased from (17.0±16.3)% to (4.9 ±4.5)% ( P 0.05) in experimental group, and from (16.8± 6.9)% to (3.2± 2.3)% in control group ( P 0.05).No side effect was found in two groups. Conclusion Two kinds of hydrotalcite can combine intragastric bile and is effective and safe in the treatment of bile reflux gastritis.