Synthesis and antifungal activity of the novel triazole compounds

Objective To design the synthesis and evaluate the antifungal active of the novel triazole compounds based on the structure of fluconazole.Methods The big N,N-disuhstituted group was introduced and a series of compounds were synthesized,all of them were confirmed bv MS and ~1H NMR,el al.The antifungal activity were also evaluated against the eight common pathogenic fungi. Results Eighteen compounds were synthesized.which exhibited activity against fungi tested.Conclusion The big N,N-disubstituted group introduced to the side chain could affected the antifungal activity.