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Synthesis and antifungal activity of triazole derivatives

Jingyi Wang

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Abstract

To study the antifungal mechanism and structure-activity relationship of the azole compounds,four triazole compounds were designed and synthesized.All of them were confirmed by 1H-NMR.Antifungal activities of title compounds were evaluated.And the results of the preliminary antifungal test showed that all compounds exhibited inhibitory effects on C.albicans and C.neoformans,especially the effects of 8d and 8b showed more potent than fluconazole.

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What this paper is about

To study the antifungal mechanism and structure-activity relationship of the azole compounds,four triazole compounds were designed and synthesized.All of them were confirmed by 1H-NMR.Antifungal activities of title compounds were evaluated.And the results of the preliminary antifungal test showed that all compounds exhibited inhibitory effects on C.albicans and C.neoformans,especially the effects of 8d and 8b showed more potent than fluconazole.

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Available abstract

To study the antifungal mechanism and structure-activity relationship of the azole compounds,four triazole compounds were designed and synthesized.All of them were confirmed by 1H-NMR.Antifungal activities of title compounds were evaluated.And the results of the preliminary antifungal test showed that all compounds exhibited inhibitory effects on C.albicans and C.neoformans,especially the effects of 8d and 8b showed more potent than fluconazole.

Key concepts: Fluconazole, Antifungal, Triazole, Azole, Chemistry, Candida albicans, Stereochemistry, Proton NMR

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