Expression of protein encoded by Rb2/p130 gene and its clinical significance in patients with non-small cell lung cancer

Objective:To determine the expressions of proteins encoded by p53,p21,and Rb2/p130 genes in patients with non-small cell lung cancer(NSCLC) and explore the relationship between their expressions and the prognosis of NSCLC.Methods:The expressions of p53,p21,and Rb2/p130 proteins were determined by immunohistochemical method in 87 patients with NSCLC,and the relationships between their expressions and the pathological types,clinical stages,and survival time were analyzed.Results:The expressions of Rb2/p130 and p21 proteins were negative in 39.1%(34/87)and 48.3%(42/87) of the patients,respectively.The expression of p53 protein was positive in 51.7%(45/87) of the patients.The absent expression of Rb2/p130 protein was negatively correlated with the differentiated grades and clinical stages(P 0.05).The positive expression of p53 protein was negatively correlated with the differentiated grades(P 0.05),not the clinical stages.The survival time of patients with positive expression of p53 protein and absent expression of Rb2/p130 protein was shorter(P 0.05).Conclusion:The positive expression of p53 protein and absent expression of Rb2/p130 protein may predict the high malignant degree and poor prognosis in patients with NSCLC.