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Effect of rapamycin on proliferated human umbilical vein endothelial cell

Xiuju Yan

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Abstract

Objective:To abserve the effect of rapamycin on the proliferation of human umbilical vein endothelial celI(HUVEC)in vitro.Methods:HUVEC were exposed to different concentrations of rapamycin (0.1ng/ml-20ng/ml) solution,and the influence of rapamycin on cell proliferation induced by VEGF was investigated by MTT assaying method.Results:Various concentrations rapamycin inhibited cell proliferation.Conclusion:rapamycin had the concentration dependent inhibitory effect in HUVEC.The mechanism of rapamycin on neovascularization is to inhibit the proliferation of HUVEC.

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What this paper is about

Objective:To abserve the effect of rapamycin on the proliferation of human umbilical vein endothelial celI(HUVEC)in vitro.Methods:HUVEC were exposed to different concentrations of rapamycin (0.1ng/ml-20ng/ml) solution,and the influence of rapamycin on cell proliferation induced by VEGF was investigated by MTT assaying method.Results:Various concentrations rapamycin inhibited cell proliferation.Conclusion:rapamycin had the concentration dependent inhibitory effect in HUVEC.The mechanism of rapamycin on neovascularization is to inhibit the proliferation of HUVEC.

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Available abstract

Objective:To abserve the effect of rapamycin on the proliferation of human umbilical vein endothelial celI(HUVEC)in vitro.Methods:HUVEC were exposed to different concentrations of rapamycin (0.1ng/ml-20ng/ml) solution,and the influence of rapamycin on cell proliferation induced by VEGF was investigated by MTT assaying method.Results:Various concentrations rapamycin inhibited cell proliferation.Conclusion:rapamycin had the concentration dependent inhibitory effect in HUVEC.The mechanism of rapamycin on neovascularization is to inhibit the proliferation of HUVEC.

Key concepts: Umbilical vein, Human umbilical vein endothelial cell, Cell growth, Sirolimus, In vitro, MTT assay, Neovascularization, Cell biology

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