State of insulin resistance in nonalcoholic fatty liver patients

Objective To explore the correlation of nonalcoholic fatty liver with insulin resistance.Methods The subjects were 85 patients with fatty liver diagnosed by B ultrasonic echograph,while the controls were 32 normal individuals.Oral glucose tolerance test(OGTT),insulin release test(IRT),c_peptide release test(CPRT) and insulin sensitivity index(ISI) were performed.Results Serum glucose,insulin levels,c_peptide levels at fasting and 0.5h,1h,2h,3h after glucose intake in the fatty liver patients were significantly higher and ISI was lower than that of controls(P0.05～0.01).There was no significant difference among fatty liver patients with different degree(P0.05).Conclusion Evident insulin resistance exsists in the patients with fatty liver,which suggests that insulin resistance may play a role in the pathogenesis of fatty liver.