Anti-inflammatory and analgesic effects of Guangaiteng

Objective To investigate the effect of Guangaiteng on anti-inflammatory and analgesia.Methods The anti-inflammatory effect of Guangaiteng was studied by the mouse ear edema model induced by Xylene and carrageenan-induced rat paw edema model.The analgesic effect was observed by using mouse acetic acid writhing and hot plate method.Results Guangaiteng significantly reduced the xyleneinduced mouse ear edema,high-,middle-,low-dose of Guangaiteng significantly reduced inflammation after 2 h,high-,middle-dose Guangaiteng significantly reduced inflammation after 4 h.Latency of Guangaiteng group was prolonged,writhing significantly was reduced and pain threshold was increased.Conclusions Guangaiteng has significant anti-inflammatory and analgesic effect.