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2002•Chinese Journal of Clinical HepatologyRequires access

The relationship of portal hemodynamics to nitric oxide and endothelin levels in patients with liver cirrhosis.

Qiou Bing

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Abstract

To study the relationships of portal hemodynamics to vasoactive substances - nitric oxide (NO) and endothelin (ET) in cirrhosis patients, 48 patients with liver cirrhosis (LC) and 32 normal controls (NC) were studied, including 18 patients with compensated LC and 30 patients with decompensated LC. Portal venous and splenic venous blood flow (PVBF and SVBF) were measured by color duplex doppler ultrasonography, and the blood coucentrations of ET and NO were detected. After analyzing the correlation between PVBF and SVBF to NO(ET), the results suggest that protal hy- perdynamic changes, which exist in cirrhosis patients from beginning to the end, were possibly due to the high NO level and the low sensitiving to ET, and it is useful for the clinical treatment.

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What this paper is about

To study the relationships of portal hemodynamics to vasoactive substances - nitric oxide (NO) and endothelin (ET) in cirrhosis patients, 48 patients with liver cirrhosis (LC) and 32 normal controls (NC) were studied, including 18 patients with compensated LC and 30 patients with decompensated LC. Portal venous and splenic venous blood flow (PVBF and SVBF) were measured by color duplex doppler ultrasonography, and the blood coucentrations of ET and NO were detected. After analyzing the correlation between PVBF and SVBF to NO(ET), the results suggest that protal hy- perdynamic changes, which exist in cirrhosis patients from beginning to the end, were possibly due to the high NO level and the low sensitiving to ET, and it is useful for the clinical treatment.

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Available abstract

To study the relationships of portal hemodynamics to vasoactive substances - nitric oxide (NO) and endothelin (ET) in cirrhosis patients, 48 patients with liver cirrhosis (LC) and 32 normal controls (NC) were studied, including 18 patients with compensated LC and 30 patients with decompensated LC. Portal venous and splenic venous blood flow (PVBF and SVBF) were measured by color duplex doppler ultrasonography, and the blood coucentrations of ET and NO were detected. After analyzing the correlation between PVBF and SVBF to NO(ET), the results suggest that protal hy- perdynamic changes, which exist in cirrhosis patients from beginning to the end, were possibly due to the high NO level and the low sensitiving to ET, and it is useful for the clinical treatment.

Key concepts: Cirrhosis, Medicine, Hemodynamics, Portal hypertension, Nitric oxide, Internal medicine, Portal venous pressure, Vasoactive

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The relationship of portal hemodynamics to nitric oxide and endothelin levels in patients with liver cirrhosis. — Research Paper | ScholarLens