Effect of propofol combined with parecoxib sodium on painless abortion

Objective:To determine the feasibility as well as the advantages and disadvantages of propofol combined with parecoxib on painless abortion.Methods:A total of 120 early pregnant women undergoing painless abortion were randomly divided into 3 groups.They received 0.05mg fentanyl followed by propofol(2mg·kg-1) intravenously,intravenous injection of propofol alone(2.5mg·kg-1),or parecoxib 40mg 10min before intravenous propofol(2mg·kg-1),respectively.Additional propofol doses(30～50mg) were applied when body-motion occurred.The changes in respiratory and circulatory functions,anesthetic and analgesic effects,postoperative recovery profile and adverse reactions were observed before and after anesthesia.Results:The operations were successful in all the subjects.Women in each group showed circulatory depression to a certain extent after anesthesia,especially in propofol alone group(P0.05).The incidence of respiratory depression was higher in fentanyl+propofol group than other groups(P0.01).The rate of insufficient analgesia in the operation and postoperative abdominal pain were significantly higher in propofol alone group(P0.05).The postoperative recovery was quicker in parecoxib+propofol group than in other groups.The propofol dose was less in 2 combination groups than in propofol alone group(P0.05).Conclusion:Propofol combined with parecoxib can fulfill the requirement for painless artificial abortion.This anesthetic combination can decrease the incidence of insufficient analgesia and respiratory depression compared with fentanyl+propofol or propofol alone.Therefore,it is suitable to apply in the painless artificial abortion.