The Association between Connexin37 Gene C1019T Polymorphism and Coronary Heart Disease.

Objective To investigate the association between gap junction protein Connexin37 gene C1019T polymorphism and coronary heart disease(CHD).Methods Using polymerase chain reaction-restrictive fragment length polymorphism(PCR-RFLP) method,the genotype and allele distribution of Connexin37 gene C1019T polymorphism in 173 CHD patients and 148 controls were analyzed.Results Distribution of Connexin37 genotype was in Hardy-Weinberg equilibrium for both groups(CHD and control groups).The frequency of TT and TC genotype in CHD group was significantly higher than in control group(54.9% vs 39.2%,P0.05);similarly,the frequency of T allele in CHD group was significantly higher than in control group(35.3% vs 23.6%,P0.01).After adjusted for the influence of age,gender and other CHD risk factors by multiple Logistic regression analysis,those who are T allele carriers(TT+TC) have as 2.34 times higher risk to suffer from CHD than those who have CC genotype(95%CI=1.03-5.32,P0.05).Conclusion Connexin37 gene C1019T polymorphism is associated with CHD risk,T allele carriers have a higher risk to suffer from CHD, T allele may serve as a genetic risk factor of coronary heart disease.