2012•Zhongguo shiyan fangjixue zazhiRequires access
Effect of Salvia miltiorrhiza Extract on Heart Rate and Myocardial Enzyme after Myocardial Ischemia/reperfusion Injury in Rats
Li Ling
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Abstract
Objective:To sudy the effect of Salvia miltiorrhiza extract on heart rate and myocardial enzyme after myocardial ischemia/reperfusion injury in rats.Method:The SD rats were randomly divided into six groups(n=8,each):sham-operation group,model group,S.miltiorrhiza extract 12.8,6.3,3.2 mg·kg-1 groups and S.miltiorrhiza injection 4×103 mg·kg-1 groups.The myocardial ischemia/reperfusion injury animal model was established by ligaturing left ventricular branch of coronary artery for 30 min and reperfusion for 30 min.The S.miltiorrhiza extract at 12.8,6.4,3.2 mg·kg-1and S.miltiorrhiza injection at crude drug 4.0 g·kg-1were injected by femoral vein after 25 min myocardial ischemia and before 5 min reperfusion,and observing the changes of heart rate and myocardial enzyme.Result:S.miltiorrhiza extract significantly inhibited the decrease of heart rate and reduced serum aspartate transaminase(AST),lactate dehydrogenase(LDH) and creatine kinase(CK) activity after myocardial ischemia/reperfusion injury in rats.Conclusion:S.miltiorrhiza extract can protect myocardial ischemia/reperfusion injury.