Effects and mechanism of the extract of Radix Salviae Miltiorrhizae on blood biochemical index in the ischemia-reperfusion injury rats

Objective: To discuss the Effects of Salvia miltiorrhiza.extract on blood biochemistry Indexes and its Mechanisms in Myocardial Ischemia Reperfusion Injury Rats.Methods: Sixty SD rats were divided into 3 groups,including sham operation group,Ischemia reperfusion group and Salvia miltiorrhiza.extract group at random,20 in each group.Myocardial Ischemia reperfusion injury model was made by ligating the left descend coronary artery.Blood samples were taken before ligation,30minutes after ligation,30 minutes after reperfusion.The content of serum cardiac troponin I(CTnI),creatine kinase(CK),creatine kinase-MB isoenzyme(CK-MB),Assay the activity of superoxide dismutase(SOD) and the contentration of malondialdehyde(MDA) were detected.Results: Salvia miltiorrhiza.Extract can decrease the content of CTnI,CK,CK-MB and increase the activity SOD,decrease the content of MDA.Conclusion: Salvia miltiorrhiza.Extract can improve the blood biochemistry Indexes of the myocardium ischemia reperfusion injury.The mechanism may be associated with the clear of oxygen free radial.