Clinical Research of Dendritic Cells Combined with Cytokine Induced Killer Cells Therapy for Advanced Colorectal Cancer

Objective To evaluate clinical effects of dendritic cells(DC) combined with cytokine induced killer cells(CIK) therapy for advanced colorectal cancer.Methods Forty advanced colorectal cancer patients were randomly divided into treatment group and control group.The treatment group was given immunotherapy combined with chemotherapy.The treatment group was also given DC and CIK at an interval of 10~14 days after chemotherapy.The control group was only given chemotherapy.T lymphocyte subtypes in peripheral blood of two groups(CD3+,CD4+,CD8+,CD4+/CD8+) were analyzed before and after treatment.Performance Status(KPS),clinical effects and side effects were observed.Results The level of CD3+ showed significant difference before and after treatment in the treatment group(P=0.001),while the levels of CD4+,CD8+,CD4+/CD8+ showed no significant difference before and after treatment(P0.05).The levels of CD3+,CD4+,CD8+,CD4+/CD8+ showed no significant difference before and after treatment in the control group(P0.05).The effective rate in treatment group and control group was 45% and 35% respectively(P0.05);The effective rate of KPS in treatment group and control group was 80% and 60% respectively,the difference was statistically significant(P0.05).Conclusion DC combined with CIK therapy can improve T lymphocyte subtypes in peripheral blood of advanced colorectal cancer patients,and it can also improve thelife quality of patients.