Laboratory diagnosis and clinical significance of gestational diabetes mellitus

Objective To study the clinical significance of the detection of oral glucose tolerance test and insulin and insulin resistance and β cell function in diagnosis of gestitional diabetes mellitus(GDM).Methods 112 cases of outpatients were divided into GDM group(62 patients) and control group(50 persons).Glucose-HK detection of oral glucose tolerance test and chemiluminescence immunoassay detection of insulin were conducted ; the index of insulin resistance and β cell function were calculated by homeostasis model assessment(HOMA) ; and the insulin resistance and β cell function of secretor was evaluated.Results The index of insulin and insulin resistance in the GDM group obviously raised,compared with the control group(P0.01); PFG、1hPG、2hPG and 3hPG of GDM group were obviously higher than those of the control group(P0.05); β cell function index of GDM group obviously reduced compared with the control group(P0.05).Conclusion The body of GDM has not only insulin resistance but also the β cell function has been damaged; so it is important to have a early diagnose and therapeutic intervene at the same time to decrease the health harm of GDM patients.