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Evaluation of Acute Toxicity and Mutagenicity of Quercetin as a Feed Additive

Suo Yanli

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Abstract

This trial was conducted to evaluate quercetin safety as a feed additive.Acute toxicity test,Ames test,micronucleus test of bone marrow cells and sperm abnormality test were performed to evaluate quercetin safety.The results showed as follows: median lethal dosage(LD50) of quecertin10 g/kg BW;twice results of Ames test with and without liver microsomal polychlorinated biphenyl revulsive(S9) were negative;the result of micronucleus test of bone marrow cells was negative and there was no cytotoxic effect on experimental animals;the result of mouse sperm abnormality test showed that there was no significant difference in different quecertin treatments(P0.05),and not in a dose-dependent manner,compared with the negative control group.Quercetin is safe as a feed additive.

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What this paper is about

This trial was conducted to evaluate quercetin safety as a feed additive.Acute toxicity test,Ames test,micronucleus test of bone marrow cells and sperm abnormality test were performed to evaluate quercetin safety.The results showed as follows: median lethal dosage(LD50) of quecertin10 g/kg BW;twice results of Ames test with and without liver microsomal polychlorinated biphenyl revulsive(S9) were negative;the result of micronucleus test of bone marrow cells was negative and there was no cytotoxic effect on experimental animals;the result of mouse sperm abnormality test showed that there was no significant difference in different quecertin treatments(P0.05),and not in a dose-dependent manner,compared with the negative control group.Quercetin is safe as a feed additive.

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Available abstract

This trial was conducted to evaluate quercetin safety as a feed additive.Acute toxicity test,Ames test,micronucleus test of bone marrow cells and sperm abnormality test were performed to evaluate quercetin safety.The results showed as follows: median lethal dosage(LD50) of quecertin10 g/kg BW;twice results of Ames test with and without liver microsomal polychlorinated biphenyl revulsive(S9) were negative;the result of micronucleus test of bone marrow cells was negative and there was no cytotoxic effect on experimental animals;the result of mouse sperm abnormality test showed that there was no significant difference in different quecertin treatments(P0.05),and not in a dose-dependent manner,compared with the negative control group.Quercetin is safe as a feed additive.

Key concepts: Ames test, Micronucleus test, Quercetin, Toxicity, Bone marrow, Sperm, Acute toxicity, Genotoxicity

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