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Changges of transforming growth factor-β_1 and matrix metalloproteinase-8 in human rheumatoid arthritis

Xu Wen

Abstract

Objective To explore the chang of transforming growth factor-β1 and matrix metalloproteinase-8 in sera.Methods The expression of TGF-β1,MMP-8 in sera in patients with RA was measured by ELISA method.Results The contents of serum TGF-β1 in patients with RA were lower than those in normal subjects.But the contents of serum MMP-8 in patients with RA were higher.Conclusion TGF-β1 and MMP-8 take part in the occurrence or development course of RA.Its plays an important role in inflammatory cell transforming and aggregating to synovial tissue.

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Key concepts: Medicine, Transforming growth factor, Matrix metalloproteinase, Matrix Metalloproteinase 3, Rheumatoid arthritis, Matrix (chemical analysis), Growth factor, Metalloproteinase