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Expression of matrix metalloproteinase-8 in human rheumatoid arthritis

Zhang Yuan-cha

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Abstract

Objective To determine the expression of matrix metalloproteinase 8 (MMP 8) in synovial fluid (SF) and plasma from individuals with rheumatoid arthritis (RA) and ankylosing spondylitis (AS),using specific monoclonal antibody reagents.Methods The MMP 8 activity in the SF and plasma of normals and patients with RA and AS was assessed by enzyme linked immunosorbent assay (ELISA).Results ① The mean MMP 8 level determined in plasma from normal human and patients with RA,AS was 1～23 μg/L.② The MMP 8 level determined in synovial fluids from normal human and patients with AS was 10～20 μg/L.③ The MMP 8 level determined in synovial fluids from patients with RA was 90～2 800 μg/L.Conclusions ① The MMP 8 level in pasma from RA patients was not higher compared with that from normal human and platients with AS.② The MMP 8 level in the synovial fluids from RA patients was remarkably higher compared with from normal human and patients with AS.

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Objective To determine the expression of matrix metalloproteinase 8 (MMP 8) in synovial fluid (SF) and plasma from individuals with rheumatoid arthritis (RA) and ankylosing spondylitis (AS),using specific monoclonal antibody reagents.Methods The MMP 8 activity in the SF and plasma of normals and patients with RA and AS was assessed by enzyme linked immunosorbent assay (ELISA).Results ① The mean MMP 8 level determined in plasma from normal human and patients with RA,AS was 1～23 μg/L.② The MMP 8 level determined in synovial fluids from normal human and patients with AS was 10～20 μg/L.③ The MMP 8 level determined in synovial fluids from patients with RA was 90～2 800 μg/L.Conclusions ① The MMP 8 level in pasma from RA patients was not higher compared with that from normal human and platients with AS.② The MMP 8 level in the synovial fluids from RA patients was remarkably higher compared with from normal human and patients with AS.

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Available abstract

Objective To determine the expression of matrix metalloproteinase 8 (MMP 8) in synovial fluid (SF) and plasma from individuals with rheumatoid arthritis (RA) and ankylosing spondylitis (AS),using specific monoclonal antibody reagents.Methods The MMP 8 activity in the SF and plasma of normals and patients with RA and AS was assessed by enzyme linked immunosorbent assay (ELISA).Results ① The mean MMP 8 level determined in plasma from normal human and patients with RA,AS was 1～23 μg/L.② The MMP 8 level determined in synovial fluids from normal human and patients with AS was 10～20 μg/L.③ The MMP 8 level determined in synovial fluids from patients with RA was 90～2 800 μg/L.Conclusions ① The MMP 8 level in pasma from RA patients was not higher compared with that from normal human and platients with AS.② The MMP 8 level in the synovial fluids from RA patients was remarkably higher compared with from normal human and patients with AS.

Key concepts: Rheumatoid arthritis, Synovial fluid, Matrix metalloproteinase, Ankylosing spondylitis, Medicine, Matrix Metalloproteinase 3, Human plasma, Monoclonal antibody

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