Efficacy of Patients with Diarrhea-Predominant Irritable Bowel Syndrome Treated with Treatment of Dispersing Stagnated Liver-Qi Invigorating Spleen and Warming Kidney

Objective:It carried on a randomized,placebo-controlled,double-blind study to evaluate the curative effect of dispersing stagnated liver-qi,invigorating spleen and warming kidney on patients with IBS-D.Methods:37 patients with IBS-D were divided randomly,18 patients were treated with the decoction of dispersing stagnated liver-qi,invigorating spleen and warming kidney,19 patients were treated with placebo treatment.Course of treatment was 8 weeks.The changes of the IBS Symptom Severity Score(SSS),the score of single item symptom and the Chinese medicine symptom integral and mental condition were observed to evaluate the security and effect.Results:In IBS-SSS,the total effectiveness in treatment group was 70.6%,in control group was 61.1%,and there was no significant difference.In Chinese Medicine syndrome,the total effectiveness in treatment group was 47.1%,in control group was 22.2%,and the treatment group was superior to the control group(P0.01).Conclusions:The method of dispersing stagnated liver-qi,invigorating spleen and warming kidney can stop diarrhea when treating IBS-D,and it is effective,practical and safe.