The Efficacy of Ursodeoxycholic Acid in Treatment of High Level Glycocholic Acid During Pregnancy

Objective: To investigate the efficacy of ursodeoxycholic acid(UDCA) in treatment of high glycocholic acid(CG) level during pregnancy.Methods: Retrospective analysis were done on 309 cases with high CG level in our hospital from January 1,2010 to December 1,2010.Comparisons were done respectively on the CG changes along gestation ages and the pregnancy outcomes in different groups with mild or severe high CG level and with(test) or without(control) UDCA treatment.Results: In mild group(300CG1000 μg·L-1),the CG level increased with gestation ages slowly but no statistically significant difference appeared in CG level before delivery [(626.2±607.4) μg·L-1 vs(694.5±534.4) μg·L-1,P0.05] and intrahepatic cholestasis of pregnancy(ICP) rate(14.2% vs 12.8%,P0.05) between test and control group.In severe group(CG≥1000 μg·L-1),CG level before delivery [(1915.7±1419.0) μg·L-1 vs(3185.2±1448.3) μg·L-1,P0.01] and ICP rate(94.1% vs 62.9%,P0.01) showed statistically significant differences between test and control group.The pregnancy outcomes of mild group were better than the severe group,including gestation ages(38.9±1.3 w vs 37.6±2.4 w,P0.05),premature delivery rate(5.4% vs 28.8%,P0.01),cesarean section rate(55.9% vs 76.9%,P0.05),neonatal birth weight [(3300±457) g vs(3109±661) g,P0.05] and Apgar's score≤7(0% vs 7.7%),except the fetal distress(5.8% vs 9.1%,P0.05).Conclusion: UDCA is effective to control the increase of CG during pregnancy and decrease ICP rate in severe group.