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2000•The Practical Journal of CancerRequires access

Expression of Fas Protein in Gastric Carcinoma and Gastric Epithelial Dysplasia and Its Significance

Ke Qian

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Abstract

Objective In order to study the influence of Fas protein on gastric tumorigenesis and development.Methods Expression of Fas protein was observed in 20 cases of normal gastric mucosa,38 cases of gastric epithelial dysplasia(GED) and 52 cases of gastric carcinoma(GC) by immunohistochemical method.Results The expression rates of Fas protein in both GC and GED were significantly higher than that in normal gastric mumosa( P 0.05).No correlation between Fas expression and PT stage,lymph node status was observed.Conclusion Fas was involved in gastric tumorigenesis,but may not be related with gastvic carcinoma progression.

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What this paper is about

Objective In order to study the influence of Fas protein on gastric tumorigenesis and development.Methods Expression of Fas protein was observed in 20 cases of normal gastric mucosa,38 cases of gastric epithelial dysplasia(GED) and 52 cases of gastric carcinoma(GC) by immunohistochemical method.Results The expression rates of Fas protein in both GC and GED were significantly higher than that in normal gastric mumosa( P 0.05).No correlation between Fas expression and PT stage,lymph node status was observed.Conclusion Fas was involved in gastric tumorigenesis,but may not be related with gastvic carcinoma progression.

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Available abstract

Objective In order to study the influence of Fas protein on gastric tumorigenesis and development.Methods Expression of Fas protein was observed in 20 cases of normal gastric mucosa,38 cases of gastric epithelial dysplasia(GED) and 52 cases of gastric carcinoma(GC) by immunohistochemical method.Results The expression rates of Fas protein in both GC and GED were significantly higher than that in normal gastric mumosa( P 0.05).No correlation between Fas expression and PT stage,lymph node status was observed.Conclusion Fas was involved in gastric tumorigenesis,but may not be related with gastvic carcinoma progression.

Key concepts: Carcinogenesis, Immunohistochemistry, Gastric carcinoma, Dysplasia, Epithelial dysplasia, Gastric mucosa, Cancer research, Medicine

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