Expression and clinical significance of Fas gene in gastric carcinoma

Objective:The expression of Fas gene in astric carcinoma and its clinical significance were studied. Methods: The expression of Fas gene in gastric carcinomas and this surrounding noncancerous mucosa of 39 patients were determined with flow mmunocytometry.Results:Both gastric carcinoma tissue and the surrounding noncancerous mucosa similarly expressed the Fas antigen,the expression was no statisitcally significance(t=1.526,P0.05).The expression was significally higher in poorly differentiated adenocarcinoma and mucinous adenocarcinoma than in papillary and tubular adenocarcinomas (P0.05).Conclusion: Fas antigen in gastric carcinoma had the low expression, treatments designed to specifically alter the apoptotic threshold may have the potential to change the natural progression of gastric carcinoma.