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2010•Zhongguo linchuang yaolixue yu zhiliaoxueRequires access

Effect of CYP2C19 genetic polymorphism on drug metabolism and individualized therapy

Yuqing Xiong

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Abstract

CYP2C19 is an important durg-metabolizing enzyme involved in the metabolism of a variety of drugs in vivo.The enzymatic activity is significantly different in different individuals and races.This paper is about the effect of CYP2C19 genetic polymorphism on drug metabolism,in order to lay down a solid theory foundation for the guidance in clinical rational administration,ensure the safety and effectiveness of clinical usage,achieving individualized therapy in its true sense.

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What this paper is about

CYP2C19 is an important durg-metabolizing enzyme involved in the metabolism of a variety of drugs in vivo.The enzymatic activity is significantly different in different individuals and races.This paper is about the effect of CYP2C19 genetic polymorphism on drug metabolism,in order to lay down a solid theory foundation for the guidance in clinical rational administration,ensure the safety and effectiveness of clinical usage,achieving individualized therapy in its true sense.

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Available abstract

CYP2C19 is an important durg-metabolizing enzyme involved in the metabolism of a variety of drugs in vivo.The enzymatic activity is significantly different in different individuals and races.This paper is about the effect of CYP2C19 genetic polymorphism on drug metabolism,in order to lay down a solid theory foundation for the guidance in clinical rational administration,ensure the safety and effectiveness of clinical usage,achieving individualized therapy in its true sense.

Key concepts: CYP2C19, Drug, Pharmacology, Drug metabolism, In vivo, Pharmacokinetics, Metabolism, Pharmacogenetics

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