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2013•Strait Pharmaceutical JournalRequires access

Effect of CYP3A4 genetic polymorphism on drug metabolism and individualized therapy

MO Ju-cai

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Abstract

CYP3A4 is an important drug metabolizing enzyme involved in the metabolism of a variety of drugs in vivo.The enzymatic activity is significantly different in different individuals and races.In this paper,we summarized the effect of CYP3A4 genetic polymorphism on drug metabolism,in order to lay down a theory foundation for the guidance in clinical rational administration,ensure the safety and effectiveness of clinical usage.

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What this paper is about

CYP3A4 is an important drug metabolizing enzyme involved in the metabolism of a variety of drugs in vivo.The enzymatic activity is significantly different in different individuals and races.In this paper,we summarized the effect of CYP3A4 genetic polymorphism on drug metabolism,in order to lay down a theory foundation for the guidance in clinical rational administration,ensure the safety and effectiveness of clinical usage.

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Available abstract

CYP3A4 is an important drug metabolizing enzyme involved in the metabolism of a variety of drugs in vivo.The enzymatic activity is significantly different in different individuals and races.In this paper,we summarized the effect of CYP3A4 genetic polymorphism on drug metabolism,in order to lay down a theory foundation for the guidance in clinical rational administration,ensure the safety and effectiveness of clinical usage.

Key concepts: CYP3A4, Drug, Pharmacology, Drug metabolism, Pharmacokinetics, Polymorphism (computer science), Pharmacogenetics, In vivo

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