QUANTITATIVE ASSESSMENT OF ACUTE CEREBRAL INFARCTION USING MALTISLICE COMPUTED TOMOGRAPHYIC PERFUSION IMAGING.

Objective:To value the use of maltislice computed tomographyic(MSCT)perfusion imaging in the assessment of acute cerebral infarction.Methods:23 patients who initially diagnosed as acute cerebral infarction were intravenously injected 100 ml iodine each as a contrast agent in 6 hours after their outbreak of infarction.The siemens semsation 4 MSCT was used to scan the patients and form time versus concentration curve analysis of the time versus concentration curves provided various perfusion measurements,including the coparision of region cerebral blood flow(rCBF)between the necrosis region and the normal region,region cerebral blood volume(rCBV),mean transit time(MTT).As a result,dynamic perfusion images with various perfusion measurements were made throught perfusion comuted tomography.Each case had to be examined by computed tomography at least once a week after his infarction.Results:20 patient of the 23 patients were found having a lower rCBF in their necrosis region compared with the other side(P0.01),17 patients were observed a shrink of the size of the infarction region compared the perfusion image in first 6 hours when they were re-examined by CT a week later(P0.05),which prove the exist of ischemic penumbra area around the infarction center.Only 3 cases indicated no obvious difference according to the CT image beteen the first 6 hours and a week later.Conclusions:The maltislice computed tomographyic perfusion imaging technology can define the infarction region and it's size at the early stage of acute cerebral infarction.It also provides clues to indicated the exist of a avascular area around the necrosis centre.