Quantitavive assessment of acute cerebral infarction using multislice computed tomographyic perfusion imaging

Objective:To value the use of multislice computed tomographyic(MSCT)perfusion imaging in the assessment of acute cerebral infarction.Methods:23 patients who initiailly diagnosed as acute cerebral infarction were intravenously injected 100～150 ml iodine each as acontrast agent in 6 hours after their outbreak of infarction. The siemens semsation 4 MSCT was used to scan the patients and form time versus concentration curve analysis of the various perfusion parameters, including the coparision of region cerebral blood flow (rCBF) , region cerebral blood volume(rCBV) and mean transit time(MTT) between the necrosis region and the normal region. As a result, dynamic perfusion images with various perfusion parameters were made throught perfusion compted tomography. Each case had to be examined by computed tomography once at least one week after his infarction.Results:20 patient of the 23 patients were found having a lower rCBF in their necrosis region compared with the other side( P 0.01), 17 patients were observed a shrink of the size of the infarction region compared the perfusion image in first 6 hours when they were counterchecked by CT a week later( P 0.05), which proves the exist of ischemic penumbra area around the infarction center. Only 3 cases indicated no obvious difference according to the CT image between the first 6 hours and a week later.Conclusions:The multislice computed tomographyic perfusion imaging technology can define the infarction region and it's size at the early stage of acute cerebral infarction. It also provides clues to indicate the exist of an avascular area around the necrosis centre.