Clinical application of whole-brain perfusion CT with 320-detector row CT system in cerebral infarction

Objective:To investigate the value and advantage of whole-brain perfusion CT with 320-detector row dynamic volumetric CT system in the diagnosis and clinical application of cerebral infarction.Methods:42 patients with cerebral infarction underwent whole-brain perfusion CT;unenhanced volume scan images,CT angiography and whole-brain perfusion images could be obtained in one order of contrast agent injection,comprehensive assessment of the 3 techniques were used to evaluate cerebral infarction.Results:In the 42 patients with cerebral infarction,there were 18 cases with ischemic penumbra(IP),which were showed in 6 of 8 patients with super-acute cerebral infarction,8 of 19 patients with acute infarction,and 4 of 15 patients with subacute infarction.Compared the core area of infarct with the contralateral corresponding region,there were statistically significant difference in CBV,CBF,MTT and TTP(P0.05).In comparing the 18 patients having IP with the infarct core area,significant statistical differences of the CBV,CBF,MTT and TTP were existed as well(P0.05).No significant difference was found in the CBV value of IP and the contralateral corresponding region(P0.05).Conclusions:Ischemic penumbra might still exist in acute or subacute cerebral infarction.The position and stenotic degree of the responsible blood vessels,the extent of the cerebral lesions and the existence of ischemic penumbra could be detected by application of whole-brain perfusion imaging with 320-detector row CT system,and comprehensive assessment of cerebral infarction could be achieved.