Surveillance of drug resistance of clinical islated bacteria from 5 Jinchang hospitals in 2005

Objective To investigate distribution of bacteria isolated from clinic and resistance to commonly used antimicrobial agents in 5 two-grade Jinchang hospitals.Methods Clinical bacterial strains isolated from above hospitals in 2005 were collected,bacterial susceptibility tests were performed using Kirby-Bauer method and the results were analyzed according to NCCLS(2005) by WHONET5.0 software.Results Five hundred and forty-six strains were isolated,365 strains((66.85%)) were gram-negative bacilli,181((33.15%)) were gram-positive cocci.The main gram-negative bacilli were Escherichia coli((16.67%)),the rate of ESBLs-producing strains of Escherichia coli and Klebsiella pneumonia was(18.68%) and(15.38%) respectively;The main gram-positive cocci was Staphylococcus aureus((15.20%)) and Coagulase negative staphylococcus((9.89%)),vancomycin-resistant Staphylococcus were not isolated.The resistant rate of Escherichia coli to fluoroquinolones and gentamycin was about or 50%;The resistant rate of Enterobacter cloacae and Citrobacter freundii to the first generation cephalosporins was up to 80%,The resistant rate of Pseudomonas aeruginosa to imipenem was(19.73%);the resistant rate of Acinetobacter baumannii to imipenem was(11.87%).Conclusion Antimicrobial resistance in clinical bacteria is serious,in order to guide rational use of antimicrobial agents and control nosocomial infection,bacteria detection should be stressed.