2008•The Chinese Journal of Modern Applied PharmacyRequires access

Efficacy and safety of Candesartan with Essential hypertension

Weijie Chen

Abstract

OBJECTIVE The efficacy and safety were analyzed in patients with mild to moderate essential hypertension treated with angiotensin Ⅱ receptor blockade candesartan.METHODS The 82 patients with essential hypertension were divided into two groups randomly,candesartan group(treat with candesartan,8 mg·d-1) and benazepril group(treat with benazepril,10 mg·d-1).The efficacy and trough/peak ratio(blood pression descend) were observed after 8 weeks. RESULTS In two groups,the blood pressure was descend significantly(P0.05),the total effective rate were 64% and 62% respectively,no significant difference in two groups(P0.05).Trough/peak ratio: SBP/DBP was 0.85/0.83 in candesartan group,SBP/DBP was 0.68/0.64 in benazepril group,the difference was significant(P0.05).CONCLUSION Treat with candesartan(8 mg·d-1) in mild to moderate essential hypertension patients is efficacy and safety,and has a high trough/peak ratio.

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Key concepts: Candesartan, Benazepril, Medicine, Essential hypertension, Blood pressure, Internal medicine, Significant difference, Angiotensin II