Observation of candesartan and fosinopril in the treatment of hypertension

Objective To investigate the clinical safety and efficacy of candesartan in the treatment of patient with mild to moderate hypertension. Methods One hundred thirty patients with mild to moderate hypertension were randomly divided into candesartan (n=66, 4～8mg/d)or fosinopril(n=64, 10～20mg/d)for 20 weeks. Ambulatory blood pressure monitoring was undertaken before and after the treatment. 24 hours mean blood pressure ,trough/peak ratio, BP in 2:00- 8:00AM, effective rate, and side effect were evaluated. Results Both SBP and DBP decreased in two groups after the treatment. The effective rates were 74% in candesartan group and 73% in fosinopril group. The trough/peak ratio in candesartan group was higher than in fosinopril group (SBP79% vs 63%, DBP 79% vs 62%). Reduction of mean SBP and DBP in candesartan group was greater than that in fosinopril group during 2:00-8:00AM. Candesartan was well tolerated. Conclusion Candesartan is safe and effective in treatment of mild to moderate hypertension.