2011•Heilongjiang Medical JournalRequires access
The Expression of BDNF and Receptor TrkB in the Brains of Intractable Epilepsy
Xiu‐Jie Wang
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Abstract
Objective To investigate the expression of brain derived neurotrophic factor(BDNF) and its receptor TrkB in the brain tissues of epilepsy.To discuss its function in the epilepsy pathogenesis.Methods 82 cases of hippocampus and temporal lobe brain tissues were studied.The expression of BDNF and TrkB were investigated by Immunohistochemistry.The patients with different pathogenesis and seizure frequency were analyzed.Results The expression of BDNF/TrkB protein was significantly increased in temporal lobe cortex and hippocampus of intractable epilepsy respectively as compared with controls in the same regions.The expression of BDNF/TrkB protein was gradually increased along with extension of pathogenesis and periodicity in temporal lobe cortex and hippocampus of epilepsy.Conclusion It is indicate that the overexpression of BDNF and TrkB in the brain tissues of patients with intractable epilepsy might play an important role in the generation and development of epilepsy.