Effects of Weiyanyihao-Recip on SOD,MDA in rats with chronic atrophic gastritis

Objective To observe the effects of Weiyanyihao-Recip on SOD、MDA in rats with CAG.Methods 60 SD rats were radomisely devided into 6 groups(10 animals in each):model group, control group,Weiyanyihao-Recip with high-dose,medium-dose and low-dose group and Weimeisu group. Except the control group received intragastrical administration of normal saline,the rest five groups underwent intragastric MNNG and ranitidine hydrochloride capsules administration to be made into CAG models. Afterwards,corresponding medication was administered to each group for 60 days.Reagent kits of SOD and MDA were employed for biochemical detection of serum.Results Compared to the model group,that of SOD level in the three Weiyanyihao-Recip hao groups significantly higher while the contents of MDA is significantly lower,and the difference was statistically significant(P 0.05 or P 0.01 ).But,there was no statistical difference between Weiyanyihao-Recip groups and Weimeisu group.Conclusion It is suggested that Weiyanyihao-Recip ean increase the level of serum SOD,decrease the content of serum MDA,which maybe contribute to treatment effect on chronic atrophic gastritis rats.