The Study of Weiweikang Treating Chronic Atrophic Gastritis and Analysis of the Prescription

Objective:To study function of Weiweikang on treating chronic atrophic gastritis(CAG) model rats.Method: Twelve rats were randomly selected from 70 Wistar rats as normal control group(normal group).The remaining 58 rats were made CAG model with the multiple stimulations for 6 weeks.The remaining 50 rats which were modelede successfully were randomly divided into five groups such as model group,Weiweikang whole formula group(the whole formula group),split part Ⅰ group(buyi group),split part Ⅱ group(quxie group)and western medicine control group(western medicine group).The rats in every groups were ig 0.9% saline(0.09 g · kg-1),Weiweikang decoction(8 g · kg-1),split part I decoction(5.5 g · kg-1),split part Ⅱ decoction(2.5 g · kg-1) and the neomycin-dimensional suspension(0.3 g · kg-1),once a day,respectively.After 90 days of treatment,the gastric mucosa pathological changes were observed,the changes of superoxide dismutas(SOD)and malonyl dialdehyd(MDA)content in blood serum were detect.Result: There was no marked difference in the different-iation of gastric mucosa pathematology and microanatomy between the whole formula group and the normal group.Compared with normal control group whose SOD is(239.88±6.32) U·mL-1and MDA is(3.17±0.02) μmol·L-1,SOD of model group with(174.59±12.81) U·mL-1decrease significantly(P0.01) and MDA of model group with(5.14±0.15) μmol·L-1 increase significantly(P0.01).Compared with model group,the other medication groups made a significant increase of SOD and made the level of MDA decrease significantly(P0.01 or P0.05);Compared with model group with SOD(174.59±12.81) U·mL-1,MDA(5.14±0.15) μmol·L-1,the other medication groups made a significant increase of SOD and the level of MDA decrease significantly(P0.01 or P0.05);Compared with the whole formula group with SOD(233.91±9.03) U·mL-1,MDA:(3.11±0.19) μmol·L-1,the buyi group and quxie group made a significant decrease of SOD and made the level of MDA increase significantly(P0.01 or P0.05);Compared with the buyi group with SOD(221.58±5.71) U·mL-1,the activity of SOD with(209.89±5.27) U·mL-1 in serum was significantly lower in quxie group rats(P0.05).Conclusion: Weiweikang can improve and reverse the gastric atrophy of experimental atrophic gastritis of rats,among which ingredinets with benefiting QI and nourishing YIN founctios play a major role and ingredients with expelling pathogen plays synergy action.Its mechanism may be related to scavenging resisting the free radicals.